Here we aim to examine how interneuron (IN) types contribute to high spatial map stability in the mouse dentate gyrus (DG). To address this question, we will perform 2- / 3-photon calcium imaging of neuron populations in head-fixed mice navigating through virtual realities.

We will apply pharmaco-/optogenetic tools to modulate IN type activity to examine its influence on population activity and behavior. By performing deca-patch recordings in acute slices, we will examine the underlying structural-functional microcircuit organization. By using artificial intelligence algorithms, we will uncover how INs contribute to internal structure of active networks & encoding of behavioural variables at the level of population codes.