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Project Collaborations

Project:

B04

Investigating the fast-spiking interneuron microcircuit topology of mouse and human neocortex

PI:

Jörg Geiger

Neuronal networks store and process information by the local structural and functional connectivity of excitatory and inhibitory neurons.  In this project we plan to investigate how fast-spiking inhibitory interneurons are embedded in cortical subnetworks with structural and functional features tailored for specific region and species-dependent computational requirements.

Graphical Abstract | Smart Figures

Project-Team

Jörg Geiger

PI, Vice Coordinator

Emilia Thoma

PhD student

Ahmed Abdelwahab

PhD student

Publications

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B04| B06

Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

Authors: Ali Rifat, Bernardino Ossola, Roland W Bürli, Lee A Dawson, Nicola L Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L Heppner, Jörg R P Geiger, Christian Madry
J Neuroinflammation
2024
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B04| B07

Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit

Authors: Yangfan Peng, Antje Bjelde, Pau Vilimelis Aceituno, Franz X. Mittermaier, Henrike Planert, Sabine Grosser, Julia Onken, Katharina Faust, Thilo Kalbhenn, Matthias Simon, Helena Radbruch, Pawel Fidzinski, Dietmar Schmitz, Henrik Alle, Martin Holtkamp, Imre Vida , Benjamin F. Grewe, Jörg R. P. Geiger
Science
2024
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B04

Gamma oscillation plasticity is mediated via parvalbumin interneurons

Authors: Michael D Hadler, Alexandra Tzilivaki, Dietmar Schmitz, Henrik Alle, Jörg R P Geiger
Science Advances
2024
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B04

Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues

Authors: Michael D Hadler, Henrik Alle, Jörg R P Geiger
Trends Pharmacol Sci
2024
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B04| B07

Membrane potential states gate synaptic consolidation in human neocortical tissue. Nat Commun.

Authors: Franz X Mittermaier, Thilo Kalbhenn, Ran Xu, Julia Onken, Katharina Faust, Thomas Sauvigny, Ulrich W Thomale, Angela M Kaindl , Martin Holtkamp, Sabine Grosser, Pawel Fidzinski, Matthias Simon, Henrik Alle, Jörg R P Geiger
Nat Commun.
2024
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B04| B07

Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions

Authors: Henrike Planert, Franz Xaver Mittermaier, Sabine Grosser, Pawel Fidzinski, Ulf Christoph Schneider, Helena Radbruch, Julia Onken, Martin Holtkamp, Dietmar Schmitz, Henrik Alle, Imre Vida, Jörg Rolf Paul Geiger ,Yangfan Peng
Nat Neurosci.
2025
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B04| B06

Homeostatic control of gamma oscillatory network activity by microglia-parvalbumin interneuron interactions

Authors: Tütüncü E*, Soso-Zdravkovic L*, Onken J, Fidzinski P, Geiger JRP, Sauer J, Gerevich Z, Madry C
in preparation
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B04| B06

Disrupted-in-schizophrenia-1 is required for normal microglia-interneuron communication in hippocampal networks

Authors: Soso-Zdravkovic L, Gerevich Z, Geiger JRP, Sauer J, Madry C
in preparation
2026
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B04| B06

Microglial control of homeostatic hippocampal network activity by THIK-1 K+ channel-dependent IL-1ß release

Authors: Surala M, Soso-Zdravkovic L, Tütüncü E, Gerevich Z, Geiger JRP, Sauer J, Madry C
in preparation
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A population approach to cortical GABAergic interneuron function

Authors: Johannes J Letzkus, Henning Sprekeler, Harald Binder, Joschka Bödecker, Ilka Diester, Claudio Elgueta, Sabine Grosser, Matthias Haberl, Akos Kulik, Matthew Larkum, Christian Leibold, Christian Madry, Hannah Monyer, James F A Poulet, Jonas-Frederic Sauer, Jan Schmoranzer, Susanne Schreiber, Julia Veit, Silvia Viana da Silva, Andreas Vlachos, Imre Vida, Jörg R P Geiger, Marlene Bartos
Neuron
2026
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