Project Collaborations
Role of dentate gyrus GABAergic interneuron types in long-term information encoding by principal cells

Project:

A01

| PI:

Marlene Bartos

Here we aim to examine how interneuron (IN) types contribute to high spatial map stability in the mouse dentate gyrus (DG). To address this question, we will perform 2- / 3-photon calcium imaging of neuron populations in head-fixed mice navigating through virtual realities.

We will apply pharmaco-/optogenetic tools to modulate IN type activity to examine its influence on population activity and behavior. By performing deca-patch recordings in acute slices, we will examine the underlying structural-functional microcircuit organization. By using artificial intelligence algorithms, we will uncover how INs contribute to internal structure of active networks & encoding of behavioural variables at the level of population codes.

Graphical Abstract | Smart Figures

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Project-Team

Marlene Bartos

PI, Coordinator

Nicolas Vetter

PhD student

Maria del Angel Ocana-Fernandez

PhD Bartos Lab (associated member)

Federico Torelli

PhD Bartos Lab (associated member)

Aurore Cazala

Postdoc Bartos Lab (associated member)
A01

Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience.

Authors: Dorthe Kaufhold, Eduardo Maristany de las Casas, Maria Del Angel Ocana-Fernandez, Aurore Cazala, Mei Yuan, Akos Kulik, Thibault Cholvin, Stefanie Steub, Jonas-Frederic Sauer, Mark D. Eyre, Claudio Elgueta, Michael Strüber, Marlene Bartos
Cell Reports
2024
A01

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice.

Authors: Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos
Nature Communications
2024
A01

Context and space coding in mossy cell population activity

Authors: Li-Wen Huang, Federico Torelli, Hung-Ling Chen, Marlene Bartos
Cell Reports
2024